Title

Mrub_2813, Mrub_2815, and Mrub_2024 genes are orthologs of E. coli b0758, b0757, and b2036 genes respectively, found in the galactose metabolism pathway.

Course

BIOL 375 Molecular Genetics

Document Type

Student Paper

Streaming Media

Publication Date

2017

Disciplines

Biochemistry | Bioinformatics | Biology | Genomics | Molecular Biology | Molecular Genetics

Description, Abstract, or Artist's Statement

This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation –Annotation Collaboration Toolkit (GENI-ACT) to predict gene function. We investigated the biological function of the genes Mrub_2813, Mrub_2815, and Mrub_2024.

We predict that Mrub_2813 encodes the enzyme galactose-1-phosphate uridylyltransferase (DNA coordinates 2854219..2855259 on the reverse strand), which is the third step of the galactose metabolism pathway (KEGG map number 00052). It catalyzes the conversion of UDP-α-D-glucose and α-D-galactose 1-phosphate to UDP-α-galactose and α-D-glucopyranose 1-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b0758], which has the gene identifier GALT.

We predict that Mrub_2815 encodes the enzyme galactokinase (DNA coordinates 2856330..2857409 on the reverse strand), which is the second step of the galactose metabolism pathway (KEGG map number 00052). It catalyzes the conversion of α-D-galactose to α-D-galactose 1-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b0757], which has the gene identifier.

We predict that Mrub_2024 encodes the enzyme UDP-galactopyranose mutase (DNA coordinates 2063660..2064787 on the reverse strand), which is the fourth step of the galactose metabolism pathway (KEGG map number 00052). It catalyzes the conversion of UDP-α-D-galactose to UDP-α-D-galactofuranose. The E. coli K12 MG1655 ortholog is predicted to be b2036, which has the gene identifier], which has the gene identifier.

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