Course
Biol-375 Molecular Genetics
Document Type
Student Paper
Publication Date
2017
Disciplines
Bioinformatics | Biology | Molecular Genetics
Description, Abstract, or Artist's Statement
We predict that Mrub_2052 encodes the enzymephosphoglucomutase (DNA coordinates 2088542..2090185 on the complement strand which is the 00521 step of the Streptomycin Biosynthesis pathway (KEGG map number 5.4.2.2). It catalyzes the conversion of D-Glucose- 6P (also known as D-glucopyranose 6-phosphate) to D-Glucose-1P (also known as α-D-glucopyranose 1-phosphate). The E. coli K12 MG1655 ortholog is predicted to be b0688, which has the gene identifier pgm. We predict that Mrub__0628 encodes the enzyme glucose-1-phosphate thymidylyltransferase (DNA coordinates 605559..606635 on the complement strand, which is the 00521 step of the Streptomycin Biosynthesis pathway (KEGG map number 2.7.7.24). It catalyzes the conversion of D-Glucose-1P to dTDP-glucose (also known as dTDP-α-D-glucose). The E. coli K12 MG1655 ortholog is predicted to be b2039, which has the gene identifier rfbA. We predict that Mrub__2034 encodes the enzyme glucose-1-phosphate thymidylyltransferase (DNA coordinates 2071868..2072941 on the complement strand, which is the 00521 step of the Streptomycin Biosynthesis pathway (KEGG map number 2.7.7.24). It catalyzes the conversion of D-Glucose-1P to dTDP-glucose (also known as dTDP-α-D-glucose). The E. coli K12 MG1655 ortholog is predicted to be b3789, which has the gene identifier rffH.
Augustana Digital Commons Citation
Hartnett, James P. and Scott, Dr. Lori. "Mrub_2052, Mrub_0628, and Mrub_2034 genes are predicted to be orthologous to b0688, b2039, and b3789 genes found in Escherichia coli, which are involved in streptomycin biosynthesis" (2017). Meiothermus ruber Genome Analysis Project.
https://digitalcommons.augustana.edu/biolmruber/28