BIOL-375: Molecular Genetics
Bioinformatics | Biology | Evolution | Genetics | Genomics | Molecular Genetics
Description, Abstract, or Artist's Statement
In this project we investigated the biological function of the genes Mrub_0680, Mrub_0836 and Mrub_0837(KEGG map number 02010). We predict these genes encode components of a Heme ATP Binding Cassette (ABC) transporter: 1) Mrub_0836 (DNA coordinates 823734..824399on the reverse strand) encodes the permease component (aka transmembrane domain), predicted to be an ortho; and 2) Mrub_0680(DNA coordinates 659484..660071 on the reverse strand) encodes the ATP-binding domain (aka nucleotide binding domain); and 3) Mrub_0837(DNA coordinates 824570..825262on the reverse strand) encodes the solute binding protein. This gene system encodes a transmembrane exporter and helper proteins which are thought to be involved in the heme transport system of cytochrome-C biosynthesis.This project is part of the Meiothermus ruber genome analysis project, which predicts gene function using the bioinformatics tools collected under the umbrella of the Guiding Education through Novel Investigation –Annotation Collaboration Toolkit (GENI-ACT).
Augustana Digital Commons Citation
Church, Sarah N. and Scott, Dr. Lori. "Mrub_0680, Mrub_0836, and Mrub_0837 found to be orthologous to E. coli CcmA, CcmB, and CcmC, respectively, coding for ABC-transport proteins involved in cytochrome-C biogenesis" (2018). Meiothermus ruber Genome Analysis Project.
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