Project Advisor(s)

Dr. Jonathan Foreman

Presentation Type

Poster Presentation

Disciplines

Chemical and Pharmacologic Phenomena | Chemicals and Drugs | Large or Food Animal and Equine Medicine | Medical Biochemistry | Medical Pharmacology | Veterinary Medicine | Veterinary Toxicology and Pharmacology

Description, Abstract, or Artist's Statement

There are no controlled studies of acetaminophen toxicity in horses. The objective was to test the hypotheses that oral acetaminophen administered at a dosage 25% higher than that sometimes used in horses would result in measurable hepatic toxicity as seen in humans and other species. Six healthy adult horses were administered 25 mg/kg acetaminophen powder in corn syrup twice daily for 30 days. Three other horses served as negative controls receiving only corn syrup. Jugular venous blood samples were obtained on days 7 and 1 before treatment; on treatment days 1, 2, 5, 8, 12, 15, 19, 22, 26 and 30; and on days 3 and 7 after treatment ceased.

Samples were analyzed the same day for complete blood counts and plasma biochemistry concentrations including hepatic and renal indices. Repeated measures analysis of variance and post hoc Tukey’s test were used to identify differences between treatment groups at a significance level of P0.05), and all measured values were within the normal range for this laboratory.

It was concluded that acetaminophen at this oral dosage was not toxic in any measurable manner to the 6 horses receiving the drug in this way. It is postulated that the use of twice daily 20 mg/kg orally should be safe for periods less than 30 days in healthy horses.

Comments

This is the culmination of several months of independent research for my senior inquiry guided by Dr. Jonathan Foreman of the University of Illinois.

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30-Day Oral Acetaminophen Tolerance in Adult Horses

There are no controlled studies of acetaminophen toxicity in horses. The objective was to test the hypotheses that oral acetaminophen administered at a dosage 25% higher than that sometimes used in horses would result in measurable hepatic toxicity as seen in humans and other species. Six healthy adult horses were administered 25 mg/kg acetaminophen powder in corn syrup twice daily for 30 days. Three other horses served as negative controls receiving only corn syrup. Jugular venous blood samples were obtained on days 7 and 1 before treatment; on treatment days 1, 2, 5, 8, 12, 15, 19, 22, 26 and 30; and on days 3 and 7 after treatment ceased.

Samples were analyzed the same day for complete blood counts and plasma biochemistry concentrations including hepatic and renal indices. Repeated measures analysis of variance and post hoc Tukey’s test were used to identify differences between treatment groups at a significance level of P0.05), and all measured values were within the normal range for this laboratory.

It was concluded that acetaminophen at this oral dosage was not toxic in any measurable manner to the 6 horses receiving the drug in this way. It is postulated that the use of twice daily 20 mg/kg orally should be safe for periods less than 30 days in healthy horses.