Course
BIOL-375: Molecular Genetics
Document Type
Student Paper
Publication Date
2018
Disciplines
Biology | Molecular Genetics
Description, Abstract, or Artist's Statement
In this project we investigated the biological function of the genes Mrub_2836, Mrub_1595, and Mrub_1596 (KEGG map number 02010). We predict these genes encode components of a Zn2+ ATP Binding Cassette (ABC) transporter: 1) Mrub_2836 (DNA coordinates 1878670-2879569 on the complement strand) encodes the substrate binding protein (aka periplasmic protein), predicted to be an ortho; and 2) Mrub_1595 (DNA coordinates 1628074-1628865 on the complement strand) encodes the permease component (aka transmembrane domain); and 3) Mrub_1596 (DNA coordinates 1628867-1629637 on the complement strand) encodes the ATP-binding protein (aka nucleotide binding domain). This is an ATP transport system that imports Zinc into the cell. This is done by coupling ATP hydrolysis to the system in order to move Zinc against the cell potential gradient. This project is part of the Meiothermus ruber genome analysis project, which predicts gene function using the bioinformatics tools collected under the umbrella of the Guiding Education through Novel Investigation –Annotation Collaboration Toolkit (GENI-ACT).
Augustana Digital Commons Citation
Dollmeyer, Austin J. and Scott, Dr. Lori. "Mrub_2836, Mrub_1595, and Mrub_1596 are orthologs of b_1857, b_1859 and b_1858 in Escherichia Coli Coding for a Zinc Uptake ABC Transporter System" (2018). Meiothermus ruber Genome Analysis Project.
https://digitalcommons.augustana.edu/biolmruber/40
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.