The goal of the M. ruber genome analysis project is to study the genes and genome organization of the bacterium Meiothermus ruber, a thermophilic bacterium found in hot springs and a few warm artificial environments. The M. ruber genome was sequenced as part of the Department of Energy Joint Genome Institute’s GEBA project (Wu et al.,2009), the goal for which was to broaden our understanding of microbial genome structure and function across the microbial Tree of Life.
The M. ruber project gives students an authentic research experience in genome analysis by performing: 1) gene annotations - using bioinformatics tools to study gene function, and 2) functional genomics - using benchtop tools common to a molecular biology lab to study gene function. The papers uploaded into this site reflect student work in both these fields of study. Students perform these projects as part of the course Molecular Genetics/BIOL375 or as independent research experiences.
Wu D et al. A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature. 2009 Dec 24;462(7276):1056-60. doi: 10.1038/nature08656.
Submissions from 2016
E. coli b3639 and b3634 are orthologs of Mrub_2047 and Mrub_1372, Rong Zheng and Dr. Lori Scott
Submissions from 2015
Environmental Processing in Meiothermus ruber: the Inorganic Phosphate ABC Transporter, Mich A. Gehrig Jr., Emma M. Segura-Fernandez, and Dr. Lori Scott